Starting with the End in Mind: Translating Academic Research into Commercial Products
13:30am Chair Introduction
Chairperson: Luís Pereira de Almeida, Professor & Group Leader, University of Coimbra
13:35am Presentation: Exosome Therapeutics: Engineering Nature’s Nanoparticle System to Deliver Genetic Medicines
- Overview of Evox’s exosome engineering platform to load and release drugs
- Exosomes to deliver AAV and expand the applicability of gene therapy
- Extra-hepatic delivery of genome editors using exosomes
- Targeted exosomes to improve delivery to specific organs and cells
Antonin (Tony) de Fougerolles, Chief Executive Officer, Evox Therapeutics
13:50am Presentation: Start Planning Early: Critical Success Factors for Establishing a Robust Supply of Raw Materials
- Critical success factors for establishing a robust supply of raw materials
- Smart preparation for initial conversations with vendors
- Streamlining negotiations of NDAs, Supply Agreements, Term Sheets, Quality Agreements
- Establishing expectations for a healthy long-term relationship with your supplier
Steven Dublin, Senior Manager, Cell & Gene Therapy EMEA, Bio-Techne
14:05am Presentation: CAR-T Manufacturing: Process Development to Clinical Trials Through to Commercialisation
- Summary on the challenges and success in manufacturing of CAR-T cells
- Evolution of the process from flasks to semi-automation.
Ketki Vispute, Associate Director, Manufacturing, Autolus Therapeutics
14:20amPresentation: Characterisation of Personalized Clonal Neo-Antigen T Cell Products As An Essential Tool for Driving Process Improvements
- Overview of Achilles’ clonal neo-antigen specific T cell (cNeT) product and its use to treat solid cancers
- How characterisation of personalized cNeT products informs process development, and longer-term relevant assays for product release.
Theres Oakes, Head of Product Characterisation, Achilles Therapeutics
14:35pm Closing Panel with Q&A
With all session participants and joined by:
Simon Jones, Professor of Paediatrics and Translational Medicine, University of Manchester