Starting with the End in Mind: Translating Academic Research into Commercial Products

07 Sep 2023
Stream 2

13:30am Chair Introduction

Chairperson: Luís Pereira de Almeida, Professor & Group Leader, University of Coimbra


13:35am Presentation: Exosome Therapeutics: Engineering Nature’s Nanoparticle System to Deliver Genetic Medicines

  • Overview of Evox’s exosome engineering platform to load and release drugs
  • Exosomes to deliver AAV and expand the applicability of gene therapy
  • Extra-hepatic delivery of genome editors using exosomes
  • Targeted exosomes to improve delivery to specific organs and cells

Antonin (Tony) de Fougerolles, Chief Executive Officer, Evox Therapeutics


13:50am Presentation: Start Planning Early: Critical Success Factors for Establishing a Robust Supply of Raw Materials

  • Critical success factors for establishing a robust supply of raw materials
    • Smart preparation for initial conversations with vendors
    • Streamlining negotiations of NDAs, Supply Agreements, Term Sheets, Quality Agreements
    • Establishing expectations for a healthy long-term relationship with your supplier

Steven Dublin, Senior Manager, Cell & Gene Therapy EMEA, Bio-Techne


14:05am Presentation: CAR-T Manufacturing: Process Development to Clinical Trials Through to Commercialisation

  • Summary on the challenges and success in manufacturing of CAR-T cells 
  • Evolution of the process from flasks to semi-automation. 

Ketki Vispute, Associate Director, Manufacturing, Autolus Therapeutics


14:20amPresentation: Characterisation of Personalized Clonal Neo-Antigen T Cell Products As An Essential Tool for Driving Process Improvements

  • Overview of Achilles’ clonal neo-antigen specific T cell (cNeT) product and its use to treat solid cancers 
  • How characterisation of personalized cNeT products informs process development, and longer-term relevant assays for product release. 

Theres Oakes, Head of Product Characterisation, Achilles Therapeutics


14:35pm Closing Panel with Q&A 

With all session participants and joined by:

Simon Jones, Professor of Paediatrics and Translational Medicine, University of Manchester



Luís Pereira de Almeida
Professor & Group Leader
University of Coimbra
Antonin de Fougerolles
Chief Executive Officer
Evox Therapeutics
Steven Dublin
Senior Manager, Cell & Gene Therapy, EMEA
Ketki Vispute
Associate Director, Manufacturing
Autolus Therapeutics
Theres Oakes
Head of Product Characterisation
Achilles Therapeutics
Simon Jones
Professor of Pediatrics and Translational Medicine
University of Manchester