13:30am Chair Introduction

Chairperson: Luís Pereira de Almeida, Professor & Group Leader, University of Coimbra

13:35am Presentation: Exosome Therapeutics: Engineering Nature’s Nanoparticle System to Deliver Genetic Medicines

• Overview of Evox’s exosome engineering platform to load and release drugs
• Exosomes to deliver AAV and expand the applicability of gene therapy
• Extra-hepatic delivery of genome editors using exosomes
• Targeted exosomes to improve delivery to specific organs and cells

Antonin (Tony) de Fougerolles, Chief Executive Officer, Evox Therapeutics

13:50am Presentation: Start Planning Early: Critical Success Factors for Establishing a Robust Supply of Raw Materials

• Critical success factors for establishing a robust supply of raw materials
  • Smart preparation for initial conversations with vendors
  • Streamlining negotiations of NDAs, Supply Agreements, Term Sheets, Quality Agreements
  • Establishing expectations for a healthy long-term relationship with your supplier

Steven Dublin, Senior Manager, Cell & Gene Therapy EMEA, Bio-Techne

14:05am Presentation: CAR-T Manufacturing: Process Development to Clinical Trials Through to Commercialisation

• Summary on the challenges and success in manufacturing of CAR-T cells 
• Evolution of the process from flasks to semi-automation. 

Ketki Vispute, Associate Director, Manufacturing, Autolus Therapeutics

14:20amPresentation: Characterisation of Personalized Clonal Neo-Antigen T Cell Products As An Essential Tool for Driving Process Improvements

• Overview of Achilles’ clonal neo-antigen specific T cell (cNeT) product and its use to treat solid cancers 
• How characterisation of personalized cNeT products informs process development, and longer-term relevant assays for product release. 

Theres Oakes, Head of Product Characterisation, Achilles Therapeutics

14:35pm Closing Panel with Q&A 

With all session participants and joined by:

Simon Jones, Professor of Paediatrics and Translational Medicine, University of Manchester